5-methoxy DMT is a naturally-occurring hallucinogenic indolealkylamine that potently activates serotonin (5-HT) receptors.^1,2 Although this compound is regulated in many countries, including the United States, it has been described as an ‘emerging psychoactive substance’ found in party pills and related mixtures.³ As 5-methoxy DMT is inactivated by monoamine oxidases, inhibitors of monoamine oxidases are often combined with 5-methoxy DMT to prolong its activity.^4,5 The pharmacological and toxicological properties of this compound have been recently reviewed.⁶ 5-methoxy DMT is regulated as a Schedule I compound in the United States. This product is intended for forensic applications.